DISEASES

Disease-gene associations mined from literature

Literature on MAP3K11

MAP3K11 [ENSP00000309597]

Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum- stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen- stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146,

Synonyms:  MAP3K11,  MAP3K11p,  hMAP3K11,  A0A024R5E6,  E9PID4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM