DISEASES

Disease-gene associations mined from literature

Literature on WAC

WAC [ENSP00000346986]

WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) . Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription . Regulates the cell-cycle checkpoint activation in response to DNA damage . Positive regulator of amino acid starvation-induced autophagy . Also acts as a negative regulator of basal autophagy . Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation . May negatively regulate the ubiquitin proteasome pathway .

Synonyms:  WAC,  A0A0A0MRT2,  A0A494C0B7,  A0A494C0C1,  A0A494C0S5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM