DISEASES

Disease-gene associations mined from literature

Literature on PARG

PARG [ENSP00000384408]

Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose) . PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated . Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG . Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress . Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP- ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters . Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 . Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming . ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880,

Synonyms:  PARG,  A0A087WX07,  A0A087WXI6,  Q86W56,  Q86W56p ...

Linkouts:  STRING  Pharos  UniProt  OMIM