DISEASES

Disease-gene associations mined from literature

Literature on AKR1B10

AKR1B10 [ENSP00000352584]

Aldo-keto reductase family 1 member B10; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans- retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4- hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose . ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440,

Synonyms:  AKR1B10,  AKR1B10p,  hAKR1B10,  O60218,  O60218p ...

Linkouts:  STRING  Pharos  UniProt  OMIM