DISEASES

Disease-gene associations mined from literature

Literature on SLC47A1

SLC47A1 [ENSP00000270570]

Multidrug and toxin extrusion protein 1; Solute transporter for tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. ECO:0000269|PubMed:16996621, ECO:0000269|PubMed:17495125,

Synonyms:  SLC47A1,  SLC47A1p,  hSLC47A1,  E7EX57,  I3L345 ...

Linkouts:  STRING  Pharos  UniProt  OMIM