DISEASES

Disease-gene associations mined from literature

Literature on TBXA2R

TBXA2R [ENSP00000393333]

Thromboxane A2 receptor; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Synonyms:  TBXA2R,  TBXA2Rp,  hTBXA2R,  K7ER80,  P21731 ...

Linkouts:  STRING  Pharos  UniProt  OMIM