DISEASES

Disease-gene associations mined from literature

Literature on GSTA1

GSTA1 [ENSP00000335620]

Glutathione S-transferase A1, N-terminally processed; Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) . It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene- 3,17-dione and may therefore play an important role in hormone biosynthesis . Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)- hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid . ; Belongs to the GST superfamily. Alpha family.

Synonyms:  GSTA1,  GSTA1p,  hGSTA1,  A0A140VJK4,  P08263 ...

Linkouts:  STRING  Pharos  UniProt  OMIM