DISEASES

Disease-gene associations mined from literature

Literature on KCNK2

KCNK2 [ENSP00000394033]

Potassium channel subfamily K member 2; Ion channel that contributes to passive transmembrane potassium transport . Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner . In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). ECO:0000269|PubMed:10784345, ECO:0000269|PubMed:11319556,

Synonyms:  KCNK2,  KCNK2p,  hKCNK2,  B4DGU6,  C9JDK1 ...

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