DISEASES

Disease-gene associations mined from literature

Literature on INTS7

INTS7 [ENSP00000355961]

Integrator complex subunit 7; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase . May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex .

Synonyms:  INTS7,  INTS7p,  hINTS7,  A0A087WXK3,  A0A087WYC2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM