DISEASES

Disease-gene associations mined from literature

Literature on VTCN1

VTCN1 [ENSP00000358470]

V-set domain-containing T-cell activation inhibitor 1; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:17509674,

Synonyms:  VTCN1,  VTCN1p,  hVTCN1,  A0A087X1M4,  Q5T2L0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM