DISEASES

Disease-gene associations mined from literature

Literature on CHAF1A

CHAF1A [ENSP00000301280]

Chromatin assembly factor 1 subunit A; Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).

Synonyms:  CHAF1A,  CHAF1Ap,  hCHAF1A,  K7EJF1,  K7EME9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM