DISEASES

Disease-gene associations mined from literature

Literature on MMP17

MMP17 [ENSP00000353767]

Matrix metalloproteinase-17; Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

Synonyms:  MMP17,  MMP17p,  hMMP17,  F5GWR3,  F5GZA7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM