DISEASES

Disease-gene associations mined from literature

Literature on GPR137B

GPR137B [ENSP00000355551]

Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome . Involved in the regulation of lysosomal morphology and autophagy .

Synonyms:  GPR137B,  GPR137Bp,  hGPR137B,  H0Y509,  O60478 ...

Linkouts:  STRING  Pharos  UniProt  OMIM