DISEASES

Disease-gene associations mined from literature

Literature on PSMD8

PSMD8 [ENSP00000215071]

26S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family.

Synonyms:  PSMD8,  PSMD8p,  hPSMD8,  HEL-S-91n,  K7EJC1 ...

Linkouts:  STRING  Pharos  UniProt