DISEASES

Disease-gene associations mined from literature

Literature on ARL6IP1

ARL6IP1 [ENSP00000306788]

ADP-ribosylation factor-like protein 6-interacting protein 1; Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity- dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules . Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself . May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation . ECO:0000269|PubMed:12754298, ECO:0000269|PubMed:24262037,

Synonyms:  ARL6IP1,  ARL6IP1p,  hARL6IP1,  A0A024QYV7,  H3BPJ2 ...

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