DISEASES

Disease-gene associations mined from literature

Literature on PAPPA

PAPPA [ENSP00000330658]

Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. ; Belongs to the peptidase M43B family.

Synonyms:  PAPPA,  Q13219,  Q13219p,  hQ13219,  3.4.24.79 ...

Linkouts:  STRING  Pharos  UniProt  OMIM