DISEASES

Disease-gene associations mined from literature

Literature on TRIM37

TRIM37 [ENSP00000262294]

E3 ubiquitin-protein ligase TRIM37; E3 ubiquitin-protein ligase required to prevent centriole reduplication . Probably acts by ubiquitinating positive regulators of centriole reduplication . Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes . Has anti-HIV activity . ; Belongs to the TRIM/RBCC family.

Synonyms:  TRIM37,  TRIM37p,  hTRIM37,  J3KS72,  J3KT32 ...

Linkouts:  STRING  Pharos  UniProt  OMIM