DISEASES

Disease-gene associations mined from literature

Literature on CIT

CIT [ENSP00000376306]

Citron Rho-interacting kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715,

Synonyms:  CIT,  F5H4K4,  H0YGG8,  H7BYJ3,  O14578 ...

Linkouts:  STRING  Pharos  UniProt  OMIM