DISEASES

Disease-gene associations mined from literature

Literature on KLHDC8B

KLHDC8B [ENSP00000327468]

Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis . Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells .

Synonyms:  KLHDC8B,  KLHDC8Bp,  hKLHDC8B,  A0A024R2X4,  Q8IXV7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM