Literature on SLC25A33
SLC25A33 [ENSP00000306328]
Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria . Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism . Also transports guanine but not adenine (deoxy)nucleotides . Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) . Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration . Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production . Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation .
Synonyms: SLC25A33, Q9BSK2, Q9BSK2p, hQ9BSK2, 84275 ...