DISEASES

Disease-gene associations mined from literature

Literature on AICDA

AICDA [ENSP00000229335]

Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation . ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894,

Synonyms:  AICDA,  AID,  H0YFL3,  H0YFP1,  H0YGF6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM