DISEASES

Disease-gene associations mined from literature

Literature on PAXBP1

PAXBP1 [ENSP00000328992]

PAX3- and PAX7-binding protein 1; Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity); Belongs to the GCF family.

Synonyms:  PAXBP1,  PAXBP1p,  hPAXBP1,  H7BZC8,  H7C2W4 ...

Linkouts:  STRING  Pharos  UniProt