DISEASES

Disease-gene associations mined from literature

Literature on PLAA

PLAA [ENSP00000380460]

Phospholipase A-2-activating protein; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP . Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes . Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). ECO:0000269|PubMed:18291623, ECO:0000269|PubMed:27753622,; Belongs to the WD repeat PLAP family.

Synonyms:  PLAA,  E5RIM3,  H0YAU9,  H0YBW4,  H0YC16 ...

Linkouts:  STRING  Pharos  UniProt  OMIM