Literature on PLEKHF1
PLEKHF1 [ENSP00000389787]
Pleckstrin homology domain-containing family F member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
Synonyms: PLEKHF1, PLEKHF1p, hPLEKHF1, K7EIX0, K7ELB8 ...