DISEASES

Disease-gene associations mined from literature

Literature on NCSTN

NCSTN [ENSP00000294785]

Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335,

Synonyms:  NCSTN,  A0A2R8YCK1,  A0A2R8YE20,  A0A2U3TZL9,  H0Y3Z4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM