DISEASES

Disease-gene associations mined from literature

Literature on MCF2L

MCF2L [ENSP00000440374]

Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 .

Synonyms:  MCF2L,  MCF2Lp,  hMCF2L,  A2A3G7,  A2A3H1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM