DISEASES

Disease-gene associations mined from literature

Literature on CLIC4

CLIC4 [ENSP00000363500]

Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930,

Synonyms:  CLIC4,  CLIC4p,  hCLIC4,  Q6FIC5,  Q9Y696 ...

Linkouts:  STRING  Pharos  UniProt  OMIM