DISEASES

Disease-gene associations mined from literature

Literature on ITLN1

ITLN1 [ENSP00000323587]

Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta- Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2- ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) . Binds to glycans from Gram-positive and Gram- negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris . Does not bind human glycans . Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes . Increases AKT phosphorylation in the absence and presence of insulin . May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption . ECO:0000269|PubMed:16531507, ECO:0000269|PubMed:23921499,

Synonyms:  ITLN1,  ITLN1p,  hITLN1,  Q8WWA0,  Q8WWA0p ...

Linkouts:  STRING  Pharos  UniProt  OMIM