DISEASES

Disease-gene associations mined from literature

Literature on DECR2

DECR2 [ENSP00000219481]

Peroxisomal 2,4-dienoyl-CoA reductase; Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Synonyms:  DECR2,  DECR2p,  hDECR2,  A0A0J9YWI0,  A0A0J9YXZ6 ...

Linkouts:  STRING  Pharos  UniProt