DISEASES

Disease-gene associations mined from literature

Literature on KCNAB2

KCNAB2 [ENSP00000367323]

Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore . Promotes KCNA4 channel closure . Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH- dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4- nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).

Synonyms:  KCNAB2,  KCNAB2p,  hKCNAB2,  A0A024R4E3,  K7EIR5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM