DISEASES

Disease-gene associations mined from literature

Literature on BTF3

BTF3 [ENSP00000369965]

Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.

Synonyms:  BTF3,  BTF3p,  hBTF3,  D6RDG3,  H0Y9Y1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM