DISEASES

Disease-gene associations mined from literature

Literature on RSPO4

RSPO4 [ENSP00000217260]

R-spondin-4; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors . Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin- dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway .

Synonyms:  RSPO4,  RSPO4p,  hRSPO4,  Q2I0M5,  Q2I0M5p ...

Linkouts:  STRING  Pharos  UniProt  OMIM