DISEASES

Disease-gene associations mined from literature

Literature on RUFY4

RUFY4 [ENSP00000363270]

RUN and FYVE domain-containing protein 4; Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE- type zinc finger.

Synonyms:  RUFY4,  RUFY4p,  hRUFY4,  C9J235,  Q6ZNE9 ...

Linkouts:  STRING  Pharos  UniProt