DISEASES

Disease-gene associations mined from literature

Literature on MADD

MADD [ENSP00000310933]

MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. ECO:0000269|PubMed:14735464, ECO:0000269|PubMed:15007167,

Synonyms:  MADD,  A0A0A0MRB5,  A0A0U1RR25,  C9J6B0,  C9JLZ9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM