DISEASES

Disease-gene associations mined from literature

Literature on SAP30L

SAP30L [ENSP00000297109]

Histone deacetylase complex subunit SAP30L; [Isoform 1]: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes . Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus . Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA . Binds phosphoinositol phosphates (phosphoinositol 3- phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import . [Isoform 3]: Functions as transcription repressor; its activity is marginally lower than that of isoform 1. ; Belongs to the SAP30 family.

Synonyms:  SAP30L,  SAP30Lp,  hSAP30L,  Q9HAJ7,  Q9HAJ7p ...

Linkouts:  STRING  Pharos  UniProt  OMIM