DISEASES

Disease-gene associations mined from literature

Literature on DNAJA1

DNAJA1 [ENSP00000369127]

DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70 . Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) . Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co- chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis . Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV . ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877,

Synonyms:  DNAJA1,  DNAJA1p,  hDNAJA1,  P31689,  P31689p ...

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