DISEASES

Disease-gene associations mined from literature

Literature on NIT1

NIT1 [ENSP00000356988]

Deaminated glutathione amidase; Catalyzes the hydrolysis of the amide bond in N-(4- oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.

Synonyms:  NIT1,  NIT1p,  hNIT1,  Q86X76,  Q86X76p ...

Linkouts:  STRING  Pharos  UniProt  OMIM