DISEASES

Disease-gene associations mined from literature

Literature on JTB

JTB [ENSP00000271843]

Protein JTB; Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity); Belongs to the JTB family.

Synonyms:  JTB,  O76095,  O76095p,  hO76095,  10899 ...

Linkouts:  STRING  Pharos  UniProt  OMIM