Literature on TOPBP1
TOPBP1 [ENSP00000260810]
DNA topoisomerase 2-binding protein 1; Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR . ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828,
Synonyms: TOPBP1, TOPBP1p, hTOPBP1, A0A2R8YD63, I3L1F2 ...