DISEASES

Disease-gene associations mined from literature

Literature on FCMR

FCMR [ENSP00000356058]

Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Synonyms:  FCMR,  E9PMT7,  E9PN59,  E9PPV1,  E9PQG1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM