Literature on SPEF2
SPEF2 [ENSP00000348314]
Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation.
Synonyms: SPEF2, SPEF2p, hSPEF2, A0A140VKD0, A0A1B0GWC1 ...