DISEASES

Disease-gene associations mined from literature

Literature on PPP1R11

PPP1R11 [ENSP00000365963]

E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 . Inhibitor of protein phosphatase 1 .

Synonyms:  PPP1R11,  PPP1R11p,  hPPP1R11,  A2BEK1,  O60927 ...

Linkouts:  STRING  Pharos  UniProt  OMIM