DISEASES

Disease-gene associations mined from literature

Literature on HSD17B8

HSD17B8 [ENSP00000363794]

Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone . The heterotetramer with CBR4 has NADH- dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis . Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD . ; Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Synonyms:  HSD17B8,  HSD17B8p,  hHSD17B8,  A0A1U9X7U3,  Q92506 ...

Linkouts:  STRING  Pharos  UniProt