DISEASES

Disease-gene associations mined from literature

Literature on GAB2

GAB2 [ENSP00000354952]

GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Synonyms:  GAB2,  GAB2p,  hGAB2,  E9PJ26,  E9PJE2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM