DISEASES

Disease-gene associations mined from literature

Literature on LSM6

LSM6 [ENSP00000296581]

U6 snRNA-associated Sm-like protein LSm6; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable); Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.

Synonyms:  LSM6,  LSM6p,  hLSM6,  P62312,  P62312p ...

Linkouts:  STRING  Pharos  UniProt  OMIM