DISEASES

Disease-gene associations mined from literature

Literature on GPR132

GPR132 [ENSP00000328818]

Probable G-protein coupled receptor 132; May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity; Belongs to the G-protein coupled receptor 1 family.

Synonyms:  GPR132,  GPR132p,  hGPR132,  A0A0G2JL29,  F8VRH8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM