DISEASES

Disease-gene associations mined from literature

Literature on INPP5K

INPP5K [ENSP00000413937]

Inositol polyphosphate 5-phosphatase K; Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate . Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate . Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:28190456,

Synonyms:  INPP5K,  INPP5Kp,  hINPP5K,  C9JQW8,  C9JZB0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM