DISEASES

Disease-gene associations mined from literature

Literature on AKR1B15

AKR1B15 [ENSP00000389289]

Aldo-keto reductase family 1 member B15; [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta- hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs . Displays strong enzymatic activity toward all-trans- retinal and 9-cis-retinal . May play a physiological role in retinoid metabolism .

Synonyms:  AKR1B15,  AKR1B15p,  hAKR1B15,  C9JRZ8,  C9JRZ8p ...

Linkouts:  STRING  Pharos  UniProt