DISEASES

Disease-gene associations mined from literature

Literature on NCOR2

NCOR2 [ENSP00000384018]

Nuclear receptor corepressor 2; Transcriptional corepressor . Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation .

Synonyms:  NCOR2,  NCOR2p,  hNCOR2,  A0A384DVL6,  C9J0Q5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM