DISEASES

Disease-gene associations mined from literature

Literature on OPRPN

OPRPN [ENSP00000382485]

Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. ; Belongs to the PROL1/PROL3 family.

Synonyms:  OPRPN,  Q99935,  Q99935p,  hQ99935,  58503 ...

Linkouts:  STRING  Pharos  UniProt  OMIM